Northfield, Ill. (June 18, 2025)— The College of American Pathologists (CAP) released updates to 23 cancer protocols to ensure that laboratories remain aligned with best practices in oncology and patient care. These updates reflect the latest guidance from the American Joint Committee on Cancer and the World Health Organization.
Key changes to cancer diagnosis protocols include:
- Gastrointestinal: New questions related to treatment effect, histologic types, and tumor size to better address multifocal invasive carcinoma with additional neoplasms.
- Pediatric: Revised accreditation requirement statements (biopsy protocols), reformatting of explanatory notes, and the addition of reference range metadata (eCP only).
- Kidney Resection: Refined language in the lymphatic and/or vascular invasion question.
- Bladder Biopsy: Expanded answer options for the muscularis propria question to better define tumor involvement.
- Pleural Mesothelioma: Histologic grade reporting required only for epithelioid mesothelioma.
- Breast Biomarker Reporting: Updated test method questions for conditional reporting.
These protocols are updated quarterly and reaffirm the CAP’s commitment to advancing cancer diagnostics and improving patient care. A full summary of revisions is available under the resources section on cap.org.
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About the College of American Pathologists
As the world’s largest organization of board-certified pathologists and leading provider of laboratory accreditation and proficiency testing programs, the College of American Pathologists (CAP) serves patients, pathologists, and the public by fostering and advocating excellence in the practice of pathology and laboratory medicine worldwide. For more information, visit the CAP Newsroom, CAP.org and yourpathologist.org to watch pathologists at work and see the stories of the patients who trust them with their care.